Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.
نویسندگان
چکیده
منابع مشابه
Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.
BACKGROUND Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS Steroids extracted with methanol from serum sample were...
متن کاملSimultaneous measurement of endogenous cortisol, cortisone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate in nails by use of UPLC-MS-MS.
Steroid hormone concentrations are mostly determined by using different body fluids as matrices and applying immunoassay techniques. However, usability of these approaches may be restricted for several reasons, including ethical barriers to invasive sampling. Therefore, we developed an ultra-performance LC-MS-MS method for high-throughput determination of concentrations of cortisol, cortisone, ...
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Conversion of dehydroepiandrosterone sulfate to androst-5-enediol-3-sulfate by soluble extracts of rat testis.
3 H-Androst-5-ene-17-one-3B-pl sulfate is converted to 3B-androst-5-ene-lW-ol-3f3-yl sulfate by soluble extracts of rat testis in the presence of added NAM%2 or NADPH2. The conversion was approximately 4 times greater than the conversion of 3H-androst-5-ene-17-one-3B_ol to 3%androst-5-ene+3@,17&diol under similar incubation conditions. The same extracts converted 3H-androst5-ene-17-one-3@-ol to...
متن کاملMetabolism of dehydroepiandrosterone sulfate and estrone-sulfate by human platelets.
The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine capacity of human platelets to produce sex steroid hormones. The DHEAS transport was evaluated through the uptake of [(3)H]-DHEAS in the presence or absence of different substrates through the organic anion transporting polypeptide (OATP) family. The activity of sulfatase enzyme was evaluated, and ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1981
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.78.8.4704